英　文

（原　著）

  1. Y. Yamada, T. Reisine, S.F. Law, Y. Ihara, A. Kubota, S. Kagimoto, M. Seino, Y. Seino, G.I. Bell and S. Seino.  Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.  Mol Endocrinol.  6 (12):2136-2142. 1992.

  2. Y. Yamada, S. Kagimoto, A. Kubota, K. Yasuda, K. Masuda, Y. Someya, Y. Ihara, Q. Li, H. Imura, S. Seino and Y. Seino.  Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.　Biochem Biophys Res Commun.  195 (2):844-852. 1993.

  3. S. Kagimoto, Y. Yamada, A. Kubota, Y. Someya, Y. Ihara, K. Yasuda, T. Kozasa, H. Imura, S. Seino and Y. Seino.  Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gia1 protein.  Biochem Biophys Res Commun.  202 (2):1188-1195. 1994.

  4. Q. Li, Y. Yamada, K. Yasuda, Y. Ihara, Y. Okamoto, P.J. Kaisaki, R. Watanabe, H. Ikeda, K. Tsuda and Y. Seino.  A cloned rat CD38-homologous protein and its expression in pancreatic islets. Biochem Biophys Res Commun. 202 (1):629-636. 1994. 

  5. S. Kagimoto, Y. Yamada, K. Yasuda, A. Kubota, Y. Ihara, T. Taniguchi, S. Seino and Y. Seino.  Somatostatin receptor subtype expression in rat, mouse and monkey tissues.  Endocrinol Metab.  1 (2):97-101. 1994. 

  6. A. Kubota, Y. Yamada, S. Kagimoto, K. Yasuda, Y. Someya, Y. Ihara, Y. Okamoto, T. Kozasa, S. Seino and Y. Seino.  Multiple effector coupling of somatostatin receptor subtype SSTRl.  Biochem Biophys Res Commun.  204 (1):176-186. 1994. 

  7. Y. Ihara, Y. Yamada, Y. Fujii, T. Gonoi, H. Yano, K. Yasuda, N. Inagaki, Y. Seino and S. Seino.   Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic b -cells. Mol Endocrinol.  9(1):121-130. 1995. 

  8. Y. Yamada, K. Masuda, Q. Li, Y. Ihara, A. Kubota, T. Miura, K. Nakamura, Y. Fujii, S. Seino and Y. Seino.  The structures of the human calcium channel a1 subunit (CACNL1A2) and b subunit (CACNLB3) genes.  Genomics.  27:312-319. 1995. 

  9. A. Kubota, Y. Yamada, T. Hayami, K. Yasuda, Y. Someya, Y. Ihara, S. Kagimoto, R. Watanabe, T. Taminato, K. Tsuda and Y. Seino.  Identification of two missense mutations in the GIP receptor gene,a functional study and association analysis with NIDDM;no evidence of association with Japanese NIDDM subjects. Diabetes. 45(12):1701-1705. 1996.

  10. T. Taniguchi, Y. Yamada, K. Yasuda, A. Kubota, Y. Ihara, S. Kagimoto, A. Kuroe, R. Watanabe, A. Inada and Y. Seino.  Expression of ryanodine receptors in a hamster pancreatic b cell-derived cell line (HIT-T15).  Endocrinol Metab.  3:135-138. 1996. 

  11. A. Kubota, Y. Yamada, K. Yasuda, Y. Someya, Y. Ihara, S. Kagimoto, R. Watanabe, A. Kuroe, H. Ishida, and Y. Seino.  Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathways.  Biochem Biophys Res Commun.  235:171-175. 1997. 

  12. A. Inada, Y. Yamada, Y. Someya, A. Kubota, K. Yasuda, Y. Ihara, S. Kagimoto, A. Kuroe, K. Tsuda, and Y. Seino. : Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats. Biochem. Biohys. Res. Commun. 253:712-718. 1998. 

  13. R. Watanabe, Y. Yamada, Y. Ihara, Y. Someya, A. Kubota, S. Kagimoto, A. Kuroe, T. Iwakura, Z.P. Shen, A. Inada, T. Adachi, N. Ban, K. Miyawaki, Y. Sunaga, K. Tsuda, and Y. Seino. : The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals. Biochem. Biohys. Res. Commun. 254:707-712. 1999.

  14. Y. Ihara, S. Toyokuni, K. Uchida, H. Odaka, T. Tanaka, H. Ikeda, H. Hiai, Y. Seino, and Y. Yamada. : Hyperglycemia causes oxidative stress in pancreatic b-cells of GK rats, a model of type 2 diabetes. Diabetes 48:927-932. 1999. 

  15. A. Inada, Y. Someya, Y. Yamada, Y. Ihara, A. Kubota, N. Ban, R. Watanabe, K. Tsuda, and Y. Seino. : CREM family regulates the insulin gene transcription by interacting with TFIID. J Biol. Chem. 274:21095-21103. 1999.

  16. K. Miyawaki, Y. Yamada, H. Yano, H. Niwa, N. Ban, Y. Ihara, A. Kubota, S. Fujimoto, M. Kajikawa, A. Kuroe, K. Tsuda, H. Hashimoto, T. Yamashita, T. Jomori, F. Tashiro, J. Miyazaki, and Y. Seino : Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc. Natl. Acad. Sci. USA. 96(26):14843-14847. 1999.

  17. T. Iwakura, S. Fujimoto, S. Kagimoto, A. Inada, A. Kubota, Y. Someya, Y. Ihara, Y. Yamada, and Y.Seino ：Sustained Enhancement of Ca(2+) Influx by Glibenclamide Induces Apoptosis in RINm5F Cells. Biochem. Biophys. Res. Commu. 271(2):422-428. 2000.

  18. Y. Ihara, Y. Yamada, S. Toyokuni, K. Miyawaki, N. Ban, T. Adachi, A. Kuroe, T. Iwakura, A. Kubota, H. Hiai, and Y. Seino : Antioxidant a-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes. FEBS Lett. 473(1):24-26. 2000.

  19. N. Ban, Y. Yamada, Y. Someya, Y. Ihara, T. Adachi, A. Kubota, R. Watanabe, A. Kuroe, A. Inada, K. Miyawaki, Y. Sunaga, Z.P. Shen, T. Iwakura, K. Tsukiyama, S. Toyokuni, K. Tsuda, and Y. Seino.：Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression. Diabetes. 49:1142-1148. 2000.

  20. S. Toyokuni, S. Yamada, M. Kashima, Y. Ihara, Y. Yamada, T. Tanaka, H. Hiai, Y. Seino, and K. Uchida. : Serum 4-hydroxy-2-nonenal-modified albumun is elevated in the patients with type 2 diabetes. Antiox Redox Signal. 2 (4): 681-685. 2000.

  21. T. Miki, T. Iwanaga, K. Nagashima, Y. Ihara, and S. Seino. : Role of ATP-sensitive K+ channels in cell survival and differenciation in the endocrine pancreas. Diabetes 50: S48-S51. 2001.

  22. Y. Yamada, A. Kuroe, Q. Li, Y. Someya, A. Kubota, Y. Ihara, Y. Tsuura, and Y. Seino. : Genonmic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients. Diabetes Metab Res Rev 17(3):213-216. 2001.

  23. F. Sugawara, Y. Yamada, A. Kuroe, Y. Someya, A. Kubota, Y. Ihara, Takahashi K, and Y. Seino. : Human TSC-22 gene: no association with type 2 diabetes. Intern. Med.  40(10):993-997. 2001.

  24. N. Ban, Y. Yamada, Y. Someya, K. Miyawaki, Y. Ihara, M. Hosokawa, S. Toyokuni, K. Tsuda, and Y. Seino. : Hepatocyte nuclear factor-1a recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Diabetes 51(5):1409-1418 2002.

  25. K. Miyawaki, Y. Yamada, N. Ban, Y. Ihara, K. Tsukiyama, H. Zhou, S. Fujimoto, A. Oku , K. Tsuda, S. Toyokuni, H. Hiai, W. Mizunoya, T. Fushiki, J.J. Holst, M. Makino, A. Tashita, Y. Kobara, Y. Tsubamoto, T. Jinnouchi, T. Jomori T, and Y. Seino: Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med. 8(7):738-742. 2002

  26. A. Inada, Y. Hamamoto, Y. Tsuura, J. Miyazaki, S. Toyokuni, Y. Ihara, K. Nagai, Y. Yamada, S. Bonner-Weir, and Y. Seino. : Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol. 2004 24(7): 2831-2841.

（著　書）

  1. S. Seino, Y. Fujii, Y. Ihara, N. Inagaki, and Y. Seino. : Voltage-dependent calcium channels in insulin-secreting cells.  In: Diabetes 1994. S. Baba and T. Kaneko (eds.) Excepta Medica, Amsterdam, p.187-192. 1995. 

  2. Y. Ihara and Y. Seino. : Oxidative stress and type 2 diabetes. In: Free radicals in chemistry, biology and medicine. T. Yoshikawa, S. Toyokuni, Y. Yamamoto and Y. Naino (eds), OICA International (UK) Limited, London, p.432-437, 2000.

  3. K. Miyawaki, Y. Ihara, A. Kuroe, N. Ban, Z.P. Shen, A. Shiraishi, K. Tsukiyama, T. Iwakura, Y. Seino, and Y. Yamada. : Molecular mechanisms of insulin secretion. In: Diabetes mellitus; Recent advances for the 21st century.  M. Shichiri, S. Shinn, and N. Hotta (eds.) Elsevier Science B.V., Amsterdam, p.27-33. 2000